GRIN lens systems for medical applications

GRIN Needle Endomikroscopes for Fluorescence Microscopy

Brain Imaging – one of the most enabling applications of GRINTECH micro-optics

 Endomicroscopy using GRINTECH lenses and assemblies allows an in-vivo imaging access to deep tissue regions in the brain, especially in non-humans. It helps to understand disease formation and progression on a cellular level of the tissue.

To support our customers even better by providing appropriate biological techniques and protocols, GRINTECH has created a partnership with Inscopix Inc. in Palo Alto, California, one of the leading technology providers in neuroscience microscopic imaging.

Beginning on December 1st, 2015 Inscopix will distribute exclusively our products in the field of non-confocal, single photon epi-fluorescence and two-photon imaging for neuroscience applications in non-humans (see also our declaration).

  • developed for deep tissue imaging (epifluorescence)
  • offered as GRIN Singlets with NA 0.5 on both sides
  • offered as GRIN Doublets with object side NA of 0.5 and image side NA of 0.19
  • GRIN-Systems offered with different lengths

Brain Imaging – one of the most enabling applications of GRINTECH micro-optics

 Endomicroscopy using GRINTECH lenses and assemblies allows an in-vivo imaging access to deep tissue regions in the brain, especially in non-humans. It helps to understand disease formation and progression on a cellular level of the tissue.

To support our customers even better by providing appropriate biological techniques and protocols, GRINTECH has created a partnership with Inscopix Inc. in Palo Alto, California, one of the leading technology providers in neuroscience microscopic imaging.

Beginning on December 1st, 2015 Inscopix will distribute exclusively our products in the field of non-confocal, single photon epi-fluorescence and two-photon imaging for neuroscience applications in non-humans (see also our declaration).

  • developed for deep tissue imaging (Multi-Photon Microscopy)
  • offered as GRIN Singlets with NA 0.5 on both sides
  • offered as GRIN Doublets with object side NA of 0.5 and image side NA of 0.19
  • GRIN-Systems offered with different lengths

Objectives for Fluorescence-Mikroscopy:

  • numerical aperture - object = 0.80 / 0.80
  • numerical aperture - imaged = 0.18 / 0.415
  • magnification 4.65x / 1.92x
  • recommended excitation wavelength 488 nm
  • mounted in stainless steel holder

 

Objectives for 2-Photon-Mikroscopy:

  • numerical aperture - object = 0.80 / 0.80
  • numerical aperture - imaged = 0.18 / 0.415
  • magnification 4.8x / 1.92x
  • recommended excitation wavelength 800 - 900 nm
  • mounted in stainless steel holder

  • compared to the previous versions with significantly increase of the usable field of view and broader chromatic correction
  • higher confocal sensitivity
  • numerical aperture - object = 0.70 - 0.75
  • numerical aperture - image = 0.32 / 0.16 
  • magnification 2.2x - 2.3x / 4.5 x
  • mounted in stainless steel

 

GRINTECH’s high-NA Endomicroscope tube with object Numerical Aperture of 0.50 features sub-micron resolution imaging with a field of view of 300 µm for CARS/2-Photon-Fluorescence/SHG modalities. It has a diameter of 3.0 or 2.2 mm and a rigid length of 178 mm. A GRIN-refractive multilens hybrid design allows chromatic and off-axis correction between 795 nm and 1029 nm.

Applications:

  • In vivo endomicroscopy
  • nonlinear optical endoscopy (CARS, SHG, TPF)
  • tissue imaging
  • proximal scanning
  • NA conversion

 

Specifikations:

GT-MO-050-009-ACR795/1029-10-50

  • Object NA:         0.50
  • Object WD in water [µm]: 100
  • Image NA: 0.09
  • Image WD in air [µm]: Approx. 500
  • Magnification: 5.6
  • Dimensions ∅ / L [mm]:         3.0 or 2.2 / 178